The long-term goal of our lab is to understand how gene expression is regulated by chromatin and how these chromatin features are encoded in the genome. Listed below are a few recently finished or on-going projects in the lab:
Investigate the binding specificity of pioneer factors in human cells
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Coordination between pioneer factor and chromatin remodelers
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Use chemical-induced chromosomal interaction (CICI) to study 3D genome function
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Identification and functional study of pioneer factors in budding yeast
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Long-distance gene regulation in budding yeast
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Biochemical analysis of pioneer factor – nucleosome interaction
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