Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize “pioneer factors” that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.


Lab News

08/22: Another collaborative work with Shixin Liu’s lab, “Origin recognition complex harbors an intrinsic nucleosome remodeling activity”, is accepted by PNAS.

08/22: Lucy presented a guest lecture in Cold Spring Harbor Yeast Genetics & Genomics course introducing our ISO methods.

07/22: Lucy’s collaborative work with Shixin Liu’s lab, “Nucleosome-directed replication origin licensing independent of a consensus DNA sequence”, is accepted by Nature Communications.

07/22: Hengye’s work, “Partitioned Usage of Chromatin Remodelers by Nucleosome-Displacing Factors”, is accepted by Cell Reports.

06/22: Lucy presented our recent works in Telluride Workshop of Chromatin Structure and Dynamics.

06/22: The project Lucy worked on during her sabbatical, “Mechanisms underlying WNT-mediated priming of human embryonic stem cells”, is accepted by Development.

02/22: Bai lab received Huck Innovative & Transformational Seed (HITS) Fund.

01/22: Mandy and Fan’s paper, “Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles”, is published in Nature Communications. Read here for the Eberly College Research News about our work.


Bai lab is grateful for fundings from NIH, NSF, PSU, and previous fellowship supports.