Lu “Lucy” Bai

Principal Investigator  [My Google Scholar Page]

Dr. Bai is an associate professor in the Department of Biochemistry and Molecular Biology and Department of Physics at Penn State University. She received her PhD in biophysics from Cornell University (PI: Dr. Michelle Wang), and postdoctoral training at Rockefeller University (PI: Dr. Fred Cross and Dr. Eric Siggia). Dr. Bai moved to the Penn State University as an assistant professor in 2012, and was promoted to associate professor in 2018. Besides her dual appointment at BMB and Physics, her group is also part of the Penn State Center for Eukaryotic Gene Regulation, which provides a highly interactive environment for the study of chromatin and gene regulation.

Hengye Chen

Graduate Student

Hengye Chen is a PhD student from Biochemistry, Microbiology and Molecular Biology program at Pennsylvania State University. He received his Bachelor degree in biotechnology from Beijing Normal University (Supervisor: Dr. Dong Yang). He then received his Master degree in biochemistry and molecular biology from Georgetown University (Supervisor: Dr. Chunling Yi) and worked as a research assistant in Dr. Yi’s Lab after graduation. He enrolled in Penn State University and joined the Bai Lab in 2016, and currently he is working on identifying nucleosome depletion factors and probing the underlying mechanisms in Saccharomyces Cerevisiae cells.

Yi Li

Graduate student

Yi Li is a PhD student from Biochemistry, Microbiology and Molecular Biology (BMMB) program at Penn State University. He received his Bachelor degree in Biology from Shandong University (Supervisor: Dr. Mingyu Wang) in China and Uppsala University (Supervisor: Dr. Fredrik Pettersson) in Sweden. He joined Bai’s Lab since January 2019 and now he is studying chromosome interaction using a yeast model.

Holly Kleinschmidt

Graduate Student

Holly Kleinschmidt is a PhD student in the Biochemistry, Microbiology, and Molecular Biology (BMMB) program at Penn State. She received her B.S. degrees in Biochemistry and Environmental Science from Saint Louis University in St. Louis, MO. In her undergraduate thesis lab, she studied the origin of life from an organic chemistry perspective (Supervisor: Dr. Paul Bracher). She joined the Bai lab in January 2020 and is studying how epigenetic factors influence pioneer factor binding in mammalian cells.

James Lee

Graduate Student

James Lee is a PhD student in Biochemistry, Microbiology and Molecular Biology. He has a BS and MS in Biology, and Biotechnology. Before graduate school, he worked as a lab manager and research technician at the Ohio State Comprehensive Cancer Center. His research interests are yeast epigenetics, and transcriptional hotspots.

Neha Patwardhan

Graduate Student

Neha Patwardhan is a PhD student at Penn State in the MCIBS program. She got her Bachelor’s in Life Sciences in affiliation with the University of Mumbai. She received her MS in molecular and cell biology at the University of Cologne and the Max Planck Institute for Biology of Ageing. She is currently working on understanding constitutively open regions in the genome and the factors involved in maintaining this state.

Leman Simpson

Graduate student

Leman Simpson is a PhD student from the Chemistry program at Penn State University. He received his bachelors degree in Biochemistry and Molecular Biology from the College of Wooster in Wooster, OH where he carried out research into structure-guided inhibitor design (supervisor: Dr. Sara ES Martin). He participated in Penn State Chemistry’s NSF REU in 2019 (supervisor: Dr. Xin Zhang). He joined the Bai lab in 2021 and is interested in studying transcriptional hot spots.

Shane D. Stoeber

Graduate Student

Shane Stoeber is a PhD student in the Biochemistry, Microbiology, and Molecular Biology (BMMB) program at Penn State University. He received his B.S. degree in Biotechnology from Florida Gulf Coast University in Ft. Myers, Fl. He joined the Bai lab in January 2021 and is interested in studying Pioneer factors and their mechanisms in Saccharomyces cerevisiae.

Cheng Xu

Graduate Student

Cheng Xu is a graduate student from Molecular, Cellular and Integrated Biological Sciences (MCIBS) program at Penn State University. He received his B.S degree from Fudan University in China with a major in Biological Sciences. In his undergraduate thesis lab, he worked on meiosis and heterochromatin in yeast and Arabidopsis (mentor: Dr. Hong Ma). Now he is developing a high-throughput screen method in mammalian cells to study the nucleosome-depleting function of pioneer factors.

Fan Zou

Graduate student

Fan Zou is a PhD student from Physics Department at Pennsylvania State University. He received his Bachelor degree in optoelectronics from Beijing Institute of Technology. Then he received his Master degree in quantum optics from Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Science. He joined Dr. Bai’s lab since 2018 and is working on gene expression noise in silenced region using yeast cells.

Cassidy Pitts

Undergraduate student

Cassidy Pitts is studying Biomedical Engineering with a minor in Biochemistry and Molecular Biology. She is a Schreyer Honor Scholar and a Millennium Scholar in cohort 7. She joined the Bai lab in January 2021 and is working with Hengye to determine proteins with similar binding patterns as Rap1. After graduation, she plans to pursue a Ph.D. in epigenetic research.

Kristen Taylor

Undergraduate student

Kristen Taylor is studying Biochemistry and Molecular Biology, Molecular Biology option. As well as undergraduate research, she is involved in several student organizations and is part of the Pride of the Lion pep band. She joined the Bai lab in January 2022 and will be working with Holly to identify factors influencing pioneer factor binding.

Past Members of the Bai Lab:

Youngdae Yoon (postdoc)
Current position: Assistant Professor, Dept of Environ Health Science, Konkuk Univ.

Daoyong Zhang (postdoc)
Current position: Professor, Institute of Cancer Research, Xuzhou Medical University

Hungyo Kharerin (postdoc)
Current position: Postdoc, Laboratoire de Physique ENS de Lyon

Manyu Du (graduate student)
Current position: Postdoc fellow @ Max Planck Institute of Immunobiology and Epigenetics

Chao Yan (graduate student)
Current position: New York Genome Center

Qian Zhang (technician)

Domenick Braccia (undergraduate, Physics, REU program)

Alexander Bowman (undergraduate, Physics)

Benson Chong (undergraduate, BMB)

Ziyan Hong (undergraduate, summer exchange program, Chang Gung University)

Jenna Johnson (undergraduate, BMB)

Evelyn Kim (undergraduate, BMB)

Haylie Kim (undergraduate, BMB, SURF award)

Seth Kodner (undergraduate, ChemE)

Alexander Kuznetsov (undergraduate, Physics, REU program)

Collin Leese-Thompson (undergraduate, BMB)

Jaron Wharton-Mohammed (undergraduate, BMB, MURE)

Larissa Cortes Morales (undergraduate, SROP)

Jessica O’Callaghan (undergraduate, ChemE, Schreyer honors college)

Ben Paskoff (undergraduate, BMB, Schreyer honors college)

Christopher Pocetti (undergraduate, Physics, REU program)

Ryan Rogers (undergraduate, BioT)

Jessica Saganowich  (undergraduate, BMB, WISER program)

George Tankosich (undergraduate, BMB)

Shuyang Wu (undergraduate, BMB, ECoS Undergraduate Research Support)

Yujie Yan (undergraduate, Physics, Schreyer honors college)

Nur Izzati Huda Zulkarnain (undergraduate, Physics, REU program)