Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize factors that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.


Lab News

01/19: Bai Lab welcomes new graduate student, Yi Li.

12/18: Fan’s review paper, “Using Time-lapse Fluorescence Microscopy to Study Gene Regulation”, is accepted by Methods.

10/18: Manyu and Lucy presented our recent work in the ASBMB meeting: Transcriptional Regulation: Chromatin and RNA Polymerase II

08/18: Cheng’s proposal “Studying epigenetic effects on pioneer factor binding and activities using dCas9-mediated epigenetic modifications” was selected for funding from the Huck Graduate Research Innovation Fund. This is a competitive award, and congratulations, Cheng!

08/18: Lucy presented recent works in the lab at Telluride workshop on Chromatin Structure and Dynamics.

07/18: Chao’s paper, “Systematic Study of Nucleosome-Displacing Factors in Budding Yeast”, is in press in Molecular Cell. Read the press release in Eberly College of Science.


Bai lab is grateful for fundings from PSU, NIH, and previous fellowship supports.