Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize “pioneer factors” that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.

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Lab News

11/20: Bai Lab received MIRA grant from NIH for our research on pioneer factors and 3D functional genome.

11/20: Our collaborative paper with the Stillman lab “Ash1 and Tup1 Dependent Repression of the Saccharomyces cerevisiae HO promoter Requires Activator-Dependent Nucleosome Eviction” is accepted by Plos Genetics.

11/20: Hungyo’s theoretical paper on nucleosome positioning “Thermodynamic Modeling of Genome-wide Nucleosome Depleted Regions in Yeast” is accepted by Plos Computational Biology.

11/20: Lucy presented our recent work in NIH / NIEHS.

08/20: Our lab attended TSRC virtual workshop on chromatin structure and dynamics.

07/20: Bai Lab received funding from NSF on our project “Light-Induced Chromosomal Interaction: A New Tool to Study Chromosome Dynamics and Its Biological Roles”.

06/20: Congratulations to Holly Kleinschmidt for getting support from the NIH eukaryotic gene regulation training grant.

Funding

Bai lab is grateful for fundings from NIH, NSF, PSU, and previous fellowship supports.