Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize “pioneer factors” that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.

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Lab News

05/24: A review paper by Shane, Holly, and Cheng, “Pioneer Factors: Nature or Nurture?”, is accepted by Critical Reviews in Biochemistry and Molecular Biology.

05/24: Yi’s paper, “DNA Methylation-Based High-Resolution Mapping of Long-Distance Chromosomal Interactions in Nucleosome-Depleted Regions”, is accepted by Nature Communications.

04/24: Congratulations to Shane Stoeber for winning the 2024 Robert T. Simpson Graduate Student Award for Innovative Research!

02/24: Congratulations to Cheng Xu on successfully defending his thesis!

01/24: Bai Lab welcomes two new graduate students, Mitchell Godin and Niral Shah, and a new undergraduate student, Taia DiPrinzio.

12/23: Congratulations to James Lee on successfully defending his thesis!

Funding

Bai lab is grateful for fundings from NIH, NSF, PSU, and previous fellowship supports.