Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize “pioneer factors” that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.

Lab News

08/20: Our lab attended TSRC virtual workshop on chromatin structure and dynamics.

06/20: Congratulations to Holly Kleinschmidt for getting support from the NIH eukaryotic gene regulation training grant.

04/20: Our collaborative work with David Stillman “Independent Recruitment of the Mediator Tail Module to the HO Promoter Suggests Mediator Core Limits Coactivator Recruitment in Saccharomyces cerevisiae” is accepted for publication by Genetics.

02/20: Lucy presented our recent work in the Institute for Quantitative Biomedicine, Rutgers University.

10/19: Mandy successfully defended her thesis. Congratulations, Dr. Du!

09/19: Fan’s paper, “Existence, Transition, and Propagation of Intermediate Silencing States in rDNA”, is published by Mol. Cell Biol. (spotlight).

Funding

Bai lab is grateful for fundings from NIH, NSF, PSU, and previous fellowship supports.