Welcome to the Bai Lab
The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize factors that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.
17/10: Lucy attended “The 2nd International Symposium of Epigenetic Mechanism and Human Health” at Wuhan, China. Manyu’s work, “Long-Distance Regulation of Gene Expression in Budding Yeast”, was presented at the meeting.
17/09: Lucy gave two talks, “Genome-wide Study of Nucleosome Depleted Factors” and “Long-Distance Regulation of Gene Expression in Budding Yeast”, at Harvard Medical School.
17/09: The Center for Eukaryotic Gene Regulation was well represented at the Cold Spring Harbor Laboratory on Mechanisms of Eukaryotic Transcription. Check out the story here.
17/08: Bai lab welcome graduate students for rotation in the fall
17/05: Manyu’s review paper “3D clustering of co-regulated genes and its effect on gene expression” was published by Current Genetics.
Bai lab is grateful for fundings from PSU, NIH, and previous fellowship supports.