HOME 2018-06-07T19:20:48+00:00

Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize factors that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.

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Lab News

18/06: Chao’s paper, “Systematic Study of Nucleosome-Displacing Factors in Budding Yeast”, is accepted by Molecular Cell.

18/05: Lucy is promoted to associate professor.

18/04: Lucy visited University of California, Santa Cruz, and John Hopkins University to present new work from the lab.

18/01: Bai lab welcome new members, James Lee, Hungyo Kharerin, and Fan Zou!

17/09: The Center for Eukaryotic Gene Regulation was well represented at the Cold Spring Harbor Laboratory on Mechanisms of Eukaryotic Transcription. Check out the story here.

Funding

Bai lab is grateful for fundings from PSU, NIH, and previous fellowship supports.