Welcome to the Bai Lab

The Bai Lab uses a variety of strategies to understand the mechanism of gene regulation by chromatin structure at different levels. Currently, we are working on two main projects: (1) to identify and characterize “pioneer factors” that can lead to nucleosome depletion and (2) to mechanistically dissect long-distance chromosomal interactions that regulate gene expression. We measure gene expression in single live cells to probe how these chromatin features affect gene expression in terms of the average level, cell-to-cell variability (noise), and dynamics. We are using budding yeast as our primary model system, but we are venturing into the mammalian cells as well. Method-wise, we are using a combination of imaging, genetics, genomics, and computational methods. We are also developing new genetics and genomics tools for the projects above.


Lab News

02/24: Congratulations to Cheng Xu on successfully defending his thesis!

01/24: Bai Lab welcomes new graduate student, Mitchell Godin and Niral Shah, and new undergraduate student, Taia DiPrinzio!

12/23: Congratulations to James Lee on successfully defending his thesis!

12/23: Lucy presented our recent work at CSHL Asia meeting and University of IOWA.

09/23: Most of the Bai lab attended the CSHL Transcription meeting and presented our recent work.

08/23: Our Center of Eukaryotic Gene Regulation organized the 39th Penn State summer symposium on chromatin and gene regulation. Record number of researchers attended. Congratulations to Cheng for getting the best student talk award!


Bai lab is grateful for fundings from NIH, NSF, PSU, and previous fellowship supports.